Effects of Aerosol Inhalation of Chuankezhi Injection on Lung Index and Tissue Morphology of Trachea, Lung and Esophagus in Guinea Pigs
10.6039/j.issn.1001-0408.2015.34.15
- VernacularTitle:喘可治注射液雾化吸入给药对豚鼠肺指数及气管、肺、食管组织形态学的影响
- Author:
Zhengdi XU
;
Xiaochun QIU
;
Shunjun XU
;
Yuxing CHEN
- Publication Type:Journal Article
- Keywords:
Chuankezhi injection;
Aerosol inhalation;
Tissue morphology;
Guinea pig
- From:
China Pharmacy
2015;(34):4798-4800
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effects of aerosol inhalation of Chuankezhi injection on lung index and tissue morphol-ogy of trachea,lung and esophagus in guinea pigs. METHODS:40 guinea pigs were randomly divided into blank control group (normal saline),Chuankezhi high-dose,medium-dose and low dose (2.48,1.24 and 0.62 ml/kg) groups. Each treatment group was administrated by inhaling the atomized injection,once a day,20 ml/kg,for consecutive 2 weeks. The general situation of guin-ea pigs was observed 1 h after each time of medication;1 h after last medication,lung index of guinea pigs was detected,as well as the tissue morphology of left lung,right lung,trachea and esophagus by HE staining. RESULTS:Compared with normal control group,the general situation of guinea pigs were normal in Chuankezhi high-dose,medium-dose and low dose groups;there was no difference in lung index and all of them were about 0.653;tissue section staining showed that no abnormal lesion was found in these tissues. CONCLUSIONS:2 weeks of aerosol inhalation of Chuankezhi injection have no significant effect on lung index and the tissue morphology of trachea,lung and esophagus of guinea pigs.
