Optimization of Processing Technology for Atractylodes lancea Stir-baking with Bran by Box-behnken Re-sponse Surface Methodology
10.6039/j.issn.1001-0408.2015.34.30
- VernacularTitle:Box-behnken效应面法优选麸炒苍术的炮制工艺
- Author:
Ping LI
;
Ge LIU
- Publication Type:Journal Article
- Keywords:
Atractylodes lancea stir-baking with bran;
Box-behnken response surface method;
Processing technology;
Atracty-lodin
- From:
China Pharmacy
2015;(34):4844-4846
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the processing technology for Atractylodes lancea stir-baking with bran. METHODS:Us-ing the content of atractylodin,yield of water-soluble extract and ethanol-soluble extract,appearance score as comprehensive in-dex,the effects of excipient amount,stir-baking time and temperature on the quality of A. lancea stir-baking with bran were investi-gated by Box-behnken design-response surface method,so as to optimize the processing technology parameters of A. lancea stir-bak-ing with bran,and verification test were conducted. RESULTS:The optimized parameters were that the excipients amount was 10% medicinal material,stir-baking at 140 ℃ for 3 min;average comprehensive score of verification test was 0.39 (RSD=2.88%,n=3),which was close to predicted value 0.38. CONCLUSIONS:Box-behnken response surface method is reasonable and feasible for the optimization of the processing technology for A. lancea stir-baking with bran.
