Formulation Improvement and Stability Study of Kangfu Cream
10.6039/j.issn.1001-0408.2015.34.32
- VernacularTitle:康肤霜处方改良及稳定性考察
- Author:
Difeng LIU
;
Yuzhu YANG
;
Lin CAI
- Publication Type:Journal Article
- Keywords:
Kangfu cream;
Formulation improvement;
Stability;
Orthogonal test
- From:
China Pharmacy
2015;(34):4850-4852
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To improve the formulation of Kangfu cream,in order to increase the stability of it. METHODS:Ac-cording to the problem that demulsion of zinc oxide and poor stability of Kangfu cream,orthogonal test was used to optimize the formulation of cream matrix with oil phase ratio (stearic acid-white vaseline-glycerol monostearate),with the amount of polysor-bate 80,triethanolamine and SG-10 as factors,using comprehensive score of glossiness,delicacy,consistence,coating and stratifi-cation(10 points as full mark)as index. The stability of the cream was validated and investigated,such as compatibility,heat-re-sisting,cold-resistant,lighting. RESULTS:The formulation were as follows as 100 g cream containing stearic acid 8 g,white vase-line 8 g,glycerol monostearate 6 g,polysorbate 80 4 g,triethanolamine 3 g,SG-10 2 g and appropriate amount of water. The comprehensive scores of the cream were >9.5 points (n=3). Compared with the cream prepared by previous formulation,the cream prepared by modified formulation had no significant change in appearance and color,and demulsion and layering hadn’t been found. CONCLUSIONS:Kangfu cream with better stability than original formulation is successfully prepared.
