(89SrCl2) Combined with Local Radiotherapy for Pain Caused by Malignant Tumor Bone Metastasis
10.6039/j.issn.1001-0408.2015.32.29
- VernacularTitle:89SrCl2联合局部放疗用于恶性肿瘤骨转移疼痛的回顾性分析
- Author:
Mengwei ZHANG
;
Hong LU
;
Liuxing WANG
;
Weijie ZHANG
;
Juncai LIU
- Publication Type:Journal Article
- Keywords:
Discandium trisulphate;
Local radiotherapy;
Malignant tumor;
Bone metastasis;
Pain
- From:
China Pharmacy
2015;(32):4546-4548
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate therapeutic efficacy of strontium dichloride (89SrCl2 ) combined with local radiotherapy for pain caused by malignant tumor bone metastasis. METHODS:115 patients with malignant tumor complicated with bone metasta-sis were analyzed retrospectively,and they received therapy regimen of 89SrCl2 combined with local radiotherapy. The amount of 89SrCl2 was calculated according to body weight of patients,and given by intravenous injection manner at the beginning of treat-ment,and then radiotherapy target section was confirmed according to iconography for irradiation. Effect of bone pain control,side effects (myelosuppression) and the effect of treatment on quality of life were evaluated at the end of treatment. RESULTS:After one month of treatment,there were 32 cases of complete remission(CR)and 62 cases of partial remission(PR),and total effec-tive rate was 81.7%;after one month of treatment,6 cases(5.1%)suffered from Ⅲ-Ⅳ degree myelosuppression;but there was none of Ⅲ-Ⅳdegree myelosuppression case after 2 months of treatment. The improvement of overall quality of life was not signifi-cant after treatment. Pain symptoms,general situation and sleep quality all improved significantly. CONCLUSIONS:89SrCl2 com-bined with local radiotherapy can control pain caused by malignant tumor bone metastasis and induce side effect,and improve quali-ty of life to certain extent.
