Simultaneous Determination of the Contents of 9 Metal Elements in Ganmaoling Granule by ICP-MS

VernacularTitle:ICP-MS法同时测定感冒灵颗粒中9种金属元素的含量Δ
Author: Xin SONG ; Xueyu HANG ; Lu WANG ; Xiaoqing FENG ; Qin WANG ; Rui XU
Publication Type:Journal Article
Keywords: ICP-MS; Ganmaoling granule; Metal element; Microwave digestion
From: China Pharmacy 2015;(30):4252-4254
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To establish a method for simultaneous determination of the contents of Cu,Pb,As,Cr,Cd,Ba, Mn,Sb and Hg in Ganmaoling granule. METHODS:ICP-MS was conducted. The sample was handled by nitric acid microwave di-gestion system,the mass concnetration of 9 metal elements were determined by ICP-MS with Ge,In,Bi as internal standard and standard substance of test element standards. RF power was 1 100 W,sampling depth was 8 mm,carrier gas was argon(Ar)with high purity and flow rate was 1.0 L/min. RESULTS:All 9 elements had good linear range between mass concentration and ion peaks (r=0.999 1-0.999 9),detection limits were in the range of 0.3-6.0μg/L;RSDs of precision,stability and reproducibility tests were no more than 6.0%;average recoveries were in the range of 80.0%-113.5%,and RSDs were in 1.0%-4.5%. CONCLUSIONS:The method is simple,rapid and accurate,and can be used for the determination of 9 metal elements in Ganmaoling granule.