Analgesia Effect of Low-dose Ketamine Combined with Sufentanil after Radical Surgery of Esophageal Can-cer

VernacularTitle:小剂量氯胺酮联合舒芬太尼对食管癌根治术后镇痛效果的影响
Author: Zhongqing NAN ; Mingxiao ZHANG
Publication Type:Journal Article
Keywords: Ketamine; Sufentanil; Radical surgery of esophageal cancer; Anesthesia
From: China Pharmacy 2015;(30):4215-4217
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To investigate the analgesia effect of low-dose ketamine combined with sufentanil after radical sur-gery of esophageal cancer. METHODS:Totally 153 patients of pre-implementation esophageal cancer surgery were randomly divid-ed into group A,B and C. After induction of anesthesia in patients in each group,patients in group A administered sufentanil 2 μg/kg;group B were treated with sufentanil 2.5 μg/kg;group C were treated with sufentanil 2 μg/kg + ketamine 85 μg/(kg·h). Visual analog(VAS)score and Ramsay score before and after anesthesia 4,8,16,24 and 48 h,analgesia pump pressing times and inci-dence of adverse reactions in each group were observed. RESULTS:Ramsay score in 4,8 and 16 h in each group were significant-ly higher than before anesthesia,the differences were statistically significant(P<0.05),however,compared with before,there was no significant difference in the Ramsay score in 48 h among each group(P<0.05);VAS scores in each group(except for group C in 48 h) at each time point were significantly higher than before,group C