Study on the Optimization of Matrix Formula of Lanlian Ertong Qingre Cataplasm
10.6039/j.issn.1001-0408.2015.31.30
- VernacularTitle:蓝连儿童清热巴布贴基质处方的优化研究
- Author:
Na LU
;
Dengke XIONG
;
Wan YANG
;
Qinghui ZENG
;
Zhijun HUANG
- Publication Type:Journal Article
- Keywords:
Lanlian ertong qingre cataplasm;
Orthogonal test;
Matrix formula;
Adhesion force;
Peel strength
- From:
China Pharmacy
2015;26(31):4412-4415
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the matrix formula of Lanlian ertong qingre cataplasm. METHODS:Taking adhesion force,peel strength and sensory description as index,the ratio of matrix framework material(sodium polyacrylate-gan hydroxyl alu-minum-tartaric acid-glycerin) was optimized with orthogonal test. The single factor test was adopted to select adhesive and filler;the amount of penetrating agent azone was screened using the in vitro penetration amount of phillyrin. RESULTS:The best matrix ratio of Lanlian ertong qingre cataplasm was sodium polyacrylate-gan hydroxyl aluminum-tartaric acid-glycerin(4.0:0.8:0.4:15);PVP K-90 was used as adhesive,and bolus alba as filler;penetration enhancers azone accounted for 2.0%. Validation test showed, prepared cataplasm had good appearance,could stick on the 5th or the 6th ball;it's peel strength was 7.5 N;all RSDs of score were lower than 4%(n=3). CONCLUSIONS:The optimized matrix formula of Lanlian ertong qingre cataplasm is simple,stable and good in molding.
