Study on Anti-tumor Effects of Vinblastine Hydrophilic Group Modified Cationic Liposomes in Tumor-bearing Mice
10.6039/j.issn.1001-0408.2015.31.07
- VernacularTitle:长春碱亲水基修饰阳离子脂质体对荷瘤小鼠的抗肿瘤作用研究
- Author:
Xuetao LI
;
Lan CHENG
;
Ying JIANG
;
Rongping YU
;
Lianqun JIA
- Publication Type:Journal Article
- Keywords:
Vinblastine;
Hydrophilic group modified;
Cationic liposomes;
S180 cells;
Mice
- From:
China Pharmacy
2015;26(31):4339-4341
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the anti-tumor effects of Vinblastine (VLB) hydrophilic group modified cationic liposomes in tumor-bearing mice. METHODS:Tumor-bearing model were induced by inoculating yellow ascites of S180 ascites tumor mice. Tumor-bearing mice were randomly divided into model group,VLB sulfate injection group,VLB liposomes group,VLB hydrophil-ic group modified liposomes group,VLB cationic liposomes group and VLB hydrophilic group modified cationic liposomes group, i.e. group A,B,C,D,E and F,with 18 mice in each group. Group A was given normal saline intravenously via mice tail,other groups were given VLB 1.5 mg/kg every 2 days for consecutive 5 times. The anti-tumor effects of different VLB preparations were compared,using living conditions,survival time,tumor volume and weight,and tissue pathological section as indexes. RE-SULTS:Compared with group A,B,C,D and E,the mice of group F were more active,and had longer survival time,smaller tumor volume and lighter tumor weight,with statistical significance(P<0.05). The tissue pathological section of mice in group F indicated that coagulation necrosis,disintegration,and dissolution of tumor cell nucleus. CONCLUSIONS:VLB hydrophilic group modified cationic liposomes have obvious anti-tumor effect,which are better than other VLB preparations.
