Protective Effects of Ketorolac Tromethamine Ophthalmic Gel against Staphylococcus aureus Corneal Ulcer in Rabbits
10.6039/j.issn.1001-0408.2015.31.22
- VernacularTitle:酮咯酸氨丁三醇眼用凝胶剂对兔金黄色葡萄球菌性角膜溃疡的保护作用
- Author:
Fang HU
;
Tingjun XU
- Publication Type:Journal Article
- Keywords:
Ketorolac tromethamine;
Ophthalmic gel;
Staphylococcus aureus;
Corneal ulcer;
Rabbit
- From:
China Pharmacy
2015;26(31):4388-4390
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study protective effects of Ketorolac tromethamine ophthalmic gel against Staphylococcus aureus corneal ulcer in rabbits. METHODS:S. aureus corneal ulcer in rabbits model was induced by corneal substance layer inoculation, and then divided into model group,positive control group (Clarithromycin ophthalmic gel),gel high-dose,medium-dose and low-dose groups(Ketorolac tromethamine ophthalmic gel 120,80,40 mg/ml),with 20 rabbits in each group. They were given re-levant medicine,once a day for 2 weeks. The keratopathy of rabbits was observed;the clinical efficacy and keratopathy score were compared. The change of ratina was observed under micrescope. RESULTS:Compared with model group,the keratopathy score de-creased while total effective rate increased in positive control group and gel groups after medication, and the effects of gel high-dose and low-dose groups were significantly lower than that of positive control group,with statistical significance(P<0.05). The retina of rabbits had not affected by the experiment. CONCLUSIONS:Ketorolac tromethamine ophthalmic gel has protective effect against S. aureus corneal ulcer in rabbits.
