Preparation and Formulation Optimization of Hyaluronic Acid-methyl Collagen-terpolymer/Adriamycin Compound Membranes-loaded Tomtalum Stent
10.6039/j.issn.1001-0408.2015.31.34
- VernacularTitle:载透明质酸-甲基胶原-三元共聚物/多柔比星复合膜的钽支架的制备及处方优化
- Author:
Fei LI
;
Jiabi LIANG
;
Zhen QI
;
Xinming GUO
- Publication Type:Journal Article
- Keywords:
Doxorubicin;
Metal tantalum stent;
Drug sustained-release system;
Electrostatic self-assembly reaction;
Orthogo-nal design
- From:
China Pharmacy
2015;26(31):4424-4426
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare Hyaluronic acid-methyl collagen-terpolymer (HEMA-MMA-MAA)/Doxorubicin com-pound membranes-loaded tantalum stent,and to optimize the formulation. METHODS:Electrostatic self-assembly reaction was ad-opted to prepare compound membranes using metal tantalum stent as carrier,hyaluronic acid,methyl collagen and terpolymer as ex-cipients. With 1 and 30 d accumulative release rate as index,orthogonal test was used to optimize mass concentrations of hyaluron-ic acid,methyl collagen and terpolymer,and validated. The drug release behavior in vitro were investigated. RESULTS:The opti-mal formulation was as hyaluronic acid 1 mg/ml,methyl collagen 4.5 mg/ml and terpolymer 100 mg/ml. 1 and 30 d accumulative release rates of prepared tantalum stent were 7.57%(RSD=2.3%,n=3) and 84.14%(RSD=2.1%,n=3),respectively. 20 d later,dissolution rate approximated to zero level rate of drug release. CONCLUSIONS:Hyaluronic acid-methyl collagen-terpoly-mer/Doxorubicin compound membranes-loaded tantalum stent with sustained-release property is prepared successfully.
