Preparation and Quality Control of Aspirin-β-cyclodextrin-PLGA Microspheres
10.6039/j.issn.1001-0408.2016.19.30
- VernacularTitle:阿司匹林-β-环糊精包合物PLGA微球的制备及其质量控制
- Author:
Jianzhong LU
;
Tingting LIU
;
Dongrui LIU
;
Lu BAI
;
Xinjie ZHAO
;
Shichen ZHANG
;
Ning MA
- Publication Type:Journal Article
- Keywords:
Aspirin;
β-cyclodextrin;
Inclusion complexes;
PLGA;
Microspheres;
Sustained-release
- From:
China Pharmacy
2016;27(19):2687-2689
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare aspirin-β-cyclodextrin-PLGA microspheres,and control its quality. METHODS:Aspirin-β-cy-clodextrin inclusion complexes were firstly prepared,and then aspirin-β-cyclodextrin-PLGA microspheres were prepared by emul-sion-solvent evaporation method. The morphology and particle size of microspheres were detected,and entrapment efficiency and accu-mulative release rate were calculated. With entrapment efficiency as index,orthogonal test was adopted to optimize stirring speed,PVA concentration,PVA volume and feed ratio. RESULTS:The optimal formulation was as follows as stirring speed of 4 000 r/min,PVA concentration of 3%(g/100 ml),PVA volume of 30 ml,feed ratio of 1∶10. Prepared microspheres were round and smooth in appear-ance. Entrapment efficiency of the microspheres was (41.79 ± 1.09)%. The diameter were regular and ranged 0.5-127.5 μm. As drug-loaded microspheres degraded,the release of aspirin was slow and its accumulative release rate was 83%within 600 h. CONCLU-SIONS:Aspirin-β-cyclodextrin-PLGA microspheres are prepared successfully with regular morphology and good sustained-release.
