Study on Preventive Effects of Arhinhor-11 on Acute Alcoholism in Mice
10.6039/j.issn.1001-0408.2016.19.20
- VernacularTitle:阿日很浩日-11味对小鼠急性酒精中毒的预防作用研究Δ
- Author:
Mei HONG
;
Hua JIN
- Publication Type:Journal Article
- Keywords:
Arhinhor-11;
Acute alcoholism;
Righting reflex;
Alcohol concentration;
Alcohol dehyrogenase;
Mice
- From:
China Pharmacy
2016;27(19):2654-2656
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the preventive effects of arhinhor-11 on acute alcoholism in mice. METHODS:48 mice were randomly divided into model group (sodium carboxymethyl cellulose),arhinhor-11 low-dose,medium-dose and high-dose groups [1.23,2.46,4.92 g(crude drug)/kg],with 12 mice in each group. Each group was given relevant medicine intragastrically, and 30 min later given 56% liquor intragastrically to induce acute alcoholism model. The disappearance time and recovery time of righting reflex were determined. 160 mice were grouped,given medicine and modeled with the same method,with 40 mice in each group. The alcohol concentration and alcohol dehydrogenase(ADH)activity in liver of 10 mice were determined 0.5,1,2,3 h af-ter giving alcohol. Other 10 mice were included in normal control (ig administration of sodium carboxymethyl cellulose). RE-SULTS:Compared with model group,the disappearance time of righting reflex were prolonged while recovery time shortened in arhinhor-11 groups,and alcohol concentration and ADH activity increased 0.5,1,2,3 h after giving alcohol (P<0.05 or P<0.01),especially 1 h after giving alcohol. 3 h after giving alcohol,alcohol concentration in blood of arhinhor-11 high-dose group decreased while ADH activity increased (P<0.05);there was no statistical significance among other arhinhor-11 groups (P>0.05). CONCLUSIONS:Arhinhor-11 has preventive effect on acute alcoholism in mice. It has a positive control effects on the alco-hol concentration in blood and ADH activity in liver.
