Preparation of Redox-responsive Pluronic F127 Micelles with High Drug-loading Efficiency
10.6039/j.issn.1001-0408.2016.19.32
- VernacularTitle:还原响应型高载药量普朗尼克F127聚合物胶束的制备
- Author:
Xingxing CHUAN
;
Yashuang YIN
;
Xueqing WANG
- Publication Type:Journal Article
- Keywords:
Redox-responsive;
Drug-loading amount;
Polymeric micelles;
Pluronic F127;
Paclitaxel
- From:
China Pharmacy
2016;27(19):2693-2696
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare redox-responsive pluronic F127 micelles with high drug-loading efficiency. METHODS:The thiol derivative F127-SH with strong hydrophobicity was synthesized by introducing tert-butyl methacrylate and cysteamine to the hydrophobic segments of F127. Paclitaxel (PTX)-loaded redox-responsive pluronic F127 micelles with high drug-loading effi-ciency(F127-SS/PTX)were prepared by film-hydration method as well as oxidation reaction of thiol groups. The diameter,encap-sulation efficiency and drug-loading amount were detected,and the change of diameter and drug release behavior of micelles were investaged under reducing environment or non-reducing environment. RESULTS:Mean diameter of F127-SS/PTX micelles was about(77.87±1.79)nm,and encapsulation efficiency and drug-loading amount were(92.73±2.35)% and(16.25±0.99)%,re-spectively. The diameter of the micelles increased rapidly and drug release rate of PTX increased significantly in the presence of 10 mmol/L dithiothreitol. CONCLUSIONS:The redox-responsive pluronic F127 micelles with high drug-loading efficiency are pre-pared successfully.
