Optimization of Freeze-drying Technology of Albendazole Nanosuspension
10.6039/j.issn.1001-0408.2015.25.39
- VernacularTitle:阿苯达唑纳米混悬液的冻干工艺优化
- Author:
Jieru REN
;
Yunfang MA
;
Jianhua WANG
;
Ji CHEN
- Publication Type:Journal Article
- Keywords:
Albendazole;
Nanosuspension;
Cryoprotectant;
Freeze-drying
- From:
China Pharmacy
2015;(25):3575-3577
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize freeze-drying technology of albendazole nanosuspension so as to prepare albendazole nanometer powder. METHODS:By adopting freeze-drying method,with particle size and Zeta potential as the indexes,single fac-tor test and verification were made on pre-freezing temperature and the type,ratio and mass fraction of cryoprotectants,and then the albendazole nanosuspension prepared by liquid phase precipitation method was made into albendazole nanometer powder. RE-SULTS:When the pre-freezing temperature was-20℃and the cryoprotectant was 4%glucose-mannitol(3∶7),the average parti-cle size of the prepared nanometer powder was (208.03 ± 2.13) nm,and average Zeta potential was (-15.53 ± 0.18) mV. CON-CLUSIONS:Albendazole nanometer powder with better particle size and potential can be prepared by freeze-drying technology.
