Study on the Anti-inflammatory,Antalgic Effects and Irritation of Fuyan Suppository
10.6039/j.issn.1001-0408.2015.25.17
- VernacularTitle:妇炎栓抗炎、镇痛与刺激性研究
- Author:
Wenbo WU
;
Lichen SUN
;
Xing LIU
- Publication Type:Journal Article
- Keywords:
Fuyan suppository;
Pharmacodynamics;
Mouse;
Rabbit
- From:
China Pharmacy
2015;(25):3504-3506
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the anti-inflammatory,antalgic effects and irritation of Fuyan suppository. METHODS:Mouse auricle swelling test(Fuyan suppository 4.5,3.0 and 1.5 g/kg for administration)and mouse vola pedis swelling test(5 min and 0.5,1,4,6 h)were employed to study the anti-inflammatory effect of Fuyan suppository. Mouse writhing response test(Fuy-an suppository 4.5,3.0 and 1.5 g/kg) was used to study the antalgic effect. Rabbit vagina mucosa irritation test was adopted to study the vaginal irritation(Fuyan suppository 1.0 g/rabbit,once daily for one week). RESULTS:Fuyan suppository at a dose of 4.5,3.0 or 1.5 g/kg could inhibit auricle swelling of mice and reduce the times of mice’s writhing response. 3.0 g/kg Fuyan suppos-itory could,at 0.5-6 h from administration,inhibit vola pedis swelling of mice and be nonirritating to the rabbit’s vagina. CON-CLUSIONS:Fuyan suppository has better anti-inflammatory and antalgic effects and is nonirritating to the rabbit’s vagina. Theoreti-cally,vaginal administration of Fuyan suppository can be considered as safe.
