Optimization of Extraction Technology of Total Volatile Oil from Cinnamomum cassia Presl. and Cyperus rotundus L. in Hegan Lipi Granules by Box-Behnken Response Surface Method
10.6039/j.issn.1001-0408.2015.25.30
- VernacularTitle:Box-Behnken响应面法优化和肝理脾颗粒中肉桂与香附总挥发油的提取工艺
- Author:
Feng ZHAO
;
Jiangying LI
;
Weihua ZHANG
- Publication Type:Journal Article
- Keywords:
Hegan lipi granules;
Cinnamomum cassia Presl.;
Cyperus rotundus L.;
Total volatile oil;
Box-Behnken response surface method;
Optimization;
Extraction
- From:
China Pharmacy
2015;(25):3545-3547
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To optimize the extraction technology of total volatile oil from Cinnamomum cassia Presl. and Cyper-us rotundus L. in Hegan lipi granules. METHODS:With the extraction rate of total volatile oil as the index,Box-Behnken response surface method was applied to investigate the effects of water amount,soaking time for medicinal materials and extraction time by distillation on the amount of the extracted volatile oil and optimize the extraction technology of total volatile oil from C. cassia Pre-sl. and C. rotundus L. in Hegan lipi granules,and verification tests were conducted. RESULTS:The relevant coefficient of the es-tablished quadratic polynomial regression model of 3 variable factors was 0.970 5. The optimal extraction technology was as follows as 5 times as much as the amount of medicinal materials of water,soaking time of 2.5 h,extraction time of 6.0 h. Verification tests showed the extraction rate of total volatile oil was 1.65%,with a deviation rate lower than 2% compared to the predicted value of 1.67%. CONCLUSIONS:The established model is reliable with good predictability. The optimal technology can be used for the ex-traction of total volatile oil from C. cassia Presl. and C. rotundus L. in Hegan lipi granules.
