Efficacy and Safety of Sodium Valproate versus Diazepam in the Treatment of Status Epilepticus in Adults:a Meta-analysis
10.6039/j.issn.1001-0408.2015.24.22
- VernacularTitle:丙戊酸钠对比地西泮治疗成人癫痫持续状态有效性和安全性的Meta分析
- Author:
Chen LIU
;
Suying YAN
;
Jing TANG
- Publication Type:Journal Article
- Keywords:
Sodium valproate;
Diazepam;
Status epilepticus;
Adults;
Meta-analysis;
Efficacy;
Safety
- From:
China Pharmacy
2015;(24):3368-3370
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To systematically evaluate the efficacy and safety of sodium valproate versus diazepam in the treat-ment of status epilepticus in adults,and to provide evidence-based reference for clinic treatment. METHODS:Retrieved from Med-line,EMBase,PubMed,Cochrane Library,CJFD,VIP datebase,CBM and Wanfang database,the randomized controlled trials (RCT) about sodium valproate (test group) versus diazepam (control group) in the treatment of status epilepticus in adults were collected. Meta-analysis was performed by using Rev Man 5.0 statistical software after extracting data and evaluating quality. RE-SULTS:A total of 5 RCTs were included,involving 276 patients. Results of Meta-analysis showed that recurrence rate of epilepsy in 48 h in test group was significantly lower than that of control group [OR=0.39,95%CI(0.16,0.96),P=0.04]. Compared with the control group,the effective rate controlling epilepsy within 2 h[OR=1.76,95%CI(0.88,3.52),P=0.11] and incidence of liver injury[RR=1.19,95%CI(0.38,3.70),P=0.77] were no significant differences. CONCLUSIONS:The efficacy and safety of sodi-um valproate was equivalent to diazepam in the treatment of status epilepticus in adults,however,sodium valproate was superior to diazepam in terms of controlling recurrent effect. Due to methodology limit of included studies,large-scale and high quality RCT are required for further validation of the conclusions.
