Study on the Quality Standard of Anti-virus Chewable Tablet
10.6039/j.issn.1001-0408.2015.24.37
- VernacularTitle:抗病毒咀嚼片的质量标准研究
- Author:
Jingwen TANG
;
Mei PAN
- Publication Type:Journal Article
- Keywords:
Anti-virus chewable tablet;
Quality standard;
TLC;
HPLC
- From:
China Pharmacy
2015;(24):3420-3422
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish the quality standard for Anti-virus chewable tablet. METHODS:TLC was used for the qualitative identification of Forsythia suspensa,Anemarrhena asphodeloides and Pogostemon cablin in Anti-virus chewable tablet, and HPLC was conducted to determine the content of forsythin in F. suspensa. The column was Diamonsil C18 with mobile phase of acetonitrile- water (20∶80,V/V) at the flow rate of 1.0 ml/min,the detection wavelength was 230 nm,column temperature was 25℃,and injection volume was 10μl. RESULTS:The test sample and the reference sample displayed same color spots on the cor-responding position in TLC diagram. The linear range of forsythin was 0.053 5-2.675 μg(r=0.999 9);RSDs of precision,stabili-ty and reproducibility tests were no more than 1.74%;average recovery was 98.94%(RSD=1.84%,n=6). CONCLUSIONS:The method is simple,rapid,accurate,reliable and reproducible,and can be used for quality control of Anti-virus chewable tablet.