Relationship between RAD51 Polymorphism and Therapeutic Efficacy of Cisplatin Chemotherapy in Cervical Cancer Patients
10.6039/j.issn.1001-0408.2015.23.17
- VernacularTitle:宫颈癌患者顺铂化疗疗效与RAD51基因多态性的关系
- Author:
Xiaochun WU
;
Xianzhen LYU
;
Yawen ZHANG
- Publication Type:Journal Article
- Keywords:
Cervical cancer;
Cisplatin;
RAD51 polymorphism
- From:
China Pharmacy
2015;(23):3220-3222
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effects of RAD51 gene polymorphism on cancer prognosis and its relationship with therapeutic efficacy of cisplatin chemotherapy in patients with cervical cancer. METHODS:193 cervical cancer patients were selected and genotyped by TaqmanTM genotyping method. Therapeutic efficacy and survival period were observed in cisplatin chemotherapy combined with radiotherapy. RESULTS:The mean survival rate and therapeutic efficacy was significantly correlated with RAD51 genotype. The patients carrying the T gene had better response to drugs,compared to patients with type GG (P<0.05),and the average survival rate significantly increased(P<0.05). CONCLUSIONS:Genetic variation in RAD51 have obvious influence on the prognosis of cervical cancer chemotherapy. Therefore,RAD51 G172T genotypes give effective prognosis information about cervical cancer patients who received cisplatin chemotherapy.
