Therapeutic Efficacy and ADR Evaluation of Amphotericin B in the Treatment of AIDS Complicating with Fungal Infections

VernacularTitle:两性霉素B治疗艾滋病合并真菌感染的疗效及不良反应评价Δ
Author: Zhongsi HONG ; Yishen CHEN ; Lin TIAN ; Jiabi LIANG ; Xiaobin ZHENG
Publication Type:Journal Article
Keywords: AIDs; Fungal infection; Amphotericin B; Therapeutic efficacy; ADR
From: China Pharmacy 2015;(23):3238-3240
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To evaluate therapeutic efficacy and ADR of amphotericin B in the treatment of AIDS combined with fungal infections retrospectively. METHODS:The cases of amphotericin B in the treatment of AIDS combined with fungal in-fections were collected our hospital. Total therapeutic efficacy,distribution of pathogenic bacteria,clearance rate and ADR were evaluated. RESULTS:89 patients were involved totally,among which 45 cases were marked effect,32 cases improved and 12 cas-es failed,with effective rate of 86.5%. The fungus were found or cultured in 76 cases,among which 64 strains were cleared,but 12 strains were not,with total clearance rate of 84.2%. There were 41 ADR cases(46.1%),while all completed the treatment ex-cept 2 developing severe renal failure(2.2%). CONCLUSIONS:Domestic amphotericin B could effectively treat AIDS complicat-ing with fungal infections,and the ADRs were acceptable.