Retrospective Analysis of Tenofovir Disoproxil Fumarate in the Treatment of Multi-drug Resistant Chronic Hepatitis B
10.6039/j.issn.1001-0408.2015.23.27
- VernacularTitle:替诺福韦酯治疗多重耐药慢性乙型肝炎的回顾性分析
- Author:
Shuhuan FENG
;
Kecheng TANG
;
Qian LI
- Publication Type:Journal Article
- Keywords:
Tenofovir disoproxil fumarate;
Multi-drug resistant;
Chronic hepatitis B
- From:
China Pharmacy
2015;(23):3251-3252
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the short-term efficacy and ADR of tenofovir disoproxil fumarate(TDF)in the treatment of multi-drug resistant chronic hepatitis B(CHB). METHODS:32 patients with multi-drug resistant CHB were analyzed retrospec-tively,and HBV drug-resistant genes were detected before treatment;there were a number of points to resistance;they were gave TDF orally. The recovery rate of serum alanine aminotransferase(ALT),HBV-DNA conversion rate,lactic acid and renal function were observed before and after treatment. RESULTS:The recovery rate of ALT reached 100% at 3 months,and the conversion rate of HBV-DNA reached 96.88%. The lactic acid levels and renal dysfunction was not found during treatment. CONCLUSIONS:TDF take effect quickly on multi-drug resistant CHB,and no obvious ADR is found.
