Efficacy Observation of Cinepazide Maleate Combined with Oxiracetam in the Treatment of Vascular Dementia
10.6039/j.issn.1001-0408.2015.23.32
- VernacularTitle:马来酸桂哌齐特联合奥拉西坦治疗血管性痴呆的临床观察
- Author:
Xiang LI
- Publication Type:Journal Article
- Keywords:
Cinepazide maleate;
Oxiracetam;
Vascular dementia
- From:
China Pharmacy
2015;(23):3263-3265
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the clinical efficacy and safety of cinepazide maleate combined with oxiracetam in the treat-ment of vascular dementia. METHODS:62 patients with vascular dementia were randomly divided into treatment group and control group,with 31 patients in each group. Patients in control group were treated with Oxiracetam injection 4g/d for 3weeks. Patients in treat-ment group were treated with cinepazide maleate 160 mg/d for 3 weeks on the basis of control group. The patients of 2 groups were exam-ined with Mini-mental State Examination (MMSE)and Activity of Daily Living Scale (ADL)before and after treatment. RESULTS:There was statistically significant difference in MMSE and ADL scores of 2 groups before and after treatment(P<0.05);MMSE score and ADL score of treatment group was better than that of control group,with statistical significance(P<0.05);Obvious ADR was not found in both groups. CONCLUSIONS:Cinepazide maleate combined with oxiracetam can significantly improve ADL and MMSE score in patients with vascular dementia,improve the quality of life,showing significant and good clinical efficacy.
