Clinical Observation of Perospirone in the Treatment of Elderly Depression
10.6039/j.issn.1001-0408.2015.23.33
- VernacularTitle:哌罗匹隆辅助治疗老年抑郁症的临床观察
- Author:
Zhongming YANG
;
En ZHANG
- Publication Type:Journal Article
- Keywords:
Perospirone;
Paroxetine;
Drug combination;
Elderly depression
- From:
China Pharmacy
2015;(23):3266-3267
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe therapeutic efficacy and side effect of perospirone in the treatment of elderly depression. METHODS:64 elderly patients with depression were randomly divided into paroxetine combined with perospirone group (drug combination group) and paroxetine group (single drug group) with 32 patients in each group. Both groups were given paroxetine 20-40 mg/d,and drug combination group was additionally given perospirone 4-8 mg/d. HAMD and CGI-SI were adopted to evalu-ate therapeutic efficacy after 8 weeks treatment,and side effect was evaluated with TESS scale;those were compared between 2 groups. RESULTS:After 8 weeks treatment,the effective rate of drug combination group and single drug group were 75.0% and 50.0%;there was statistical significance(P<0.05). There was statistically significant difference in HAMD and CGI-SI scores be-tween two groups(P<0.05). There was no statistically significant difference in the incidence of ADR between 2 groups(P>0.05). CONCLUSIONS:Small-dose of perospirone can improve therapeutic efficacy of paroxetine in the treatment of elderly depression with less side effect and good safety.
