Efficacy Observation of Mosapride Combined with Flupentixol Melitracen in the Treatment of Elderly Func-tional Heartburn
10.6039/j.issn.1001-0408.2015.23.37
- VernacularTitle:莫沙比利联合氟哌噻吨美利曲辛治疗老年人功能性烧心的疗效观察
- Author:
Lei XU
;
Xingjie SHANG
;
Hongguang LI
- Publication Type:Journal Article
- Keywords:
Functional heartburn;
Psychological factors;
Flupentixol melitracen
- From:
China Pharmacy
2015;(23):3275-3277
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe clinical efficacy and safety of mosapride combined with flupentixol melitracen in the treat-ment of elderly functional heartburn. METHODS:106 elderly patients with functional heartburn in accordance with Rome IIIstan-dard were randomly divided into control group(52 cases)and treatment group(54 cases). The control group was treated with Mo-sapride dispersible tablets 5mg,tid,orally;the treatment group was additionally given Flupentixol melitracen tablets(containing flu-pentixol 0.5 mg and melitracen 10 mg),qd,on the basis of control group. Therapeutic efficacy of 2 groups were observed after 4 weeks. Hamilton anxiety scale(HAMA),Hamilton depressive scale(HAMD) and symptom score were conducted before and after treatment. RESULTS:The total effective rate of treatment group and control group were 87.0%and 53.8%;with statistical signifi-cance(P<0.05);there was statistical significance in symptom score,HAMA score and HAMD score between 2 groups after treatment (P<0.01). No severe ADR was found in 2 groups. CONCLUSIONS:Mosapride combined with flupentixol melitracen is safe and ef-fective in the treatment of elderly functional heartburn.
