Randomized Control Trial of Xuebijing Injection in Adjuvant Treatment of Children with Perforated Appen-dicitis
10.6039/j.issn.1001-0408.2015.23.38
- VernacularTitle:血必净注射液辅助治疗小儿穿孔性阑尾炎的随机对照试验
- Author:
Qiang FU
;
Zhenjie CAO
;
Junpeng DU
;
Yanli REN
- Publication Type:Journal Article
- Keywords:
Xuebijing injection;
Appendicitis in children;
Perforation
- From:
China Pharmacy
2015;(23):3278-3279
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the efficacy and safety of Xuebijing injection in the adjuvant treatment of children with perforated appendicitis. METHODS:72 children with perforated appendicitis in the Dept. of Pediatric General Surgery of our hospi-tal were enrolled into a prospective clinical trial,and randomly divided into experimental group (n=36) and control group (n=36). Both groups received the emergency surgery and anti-infective treatment;experimental group had additionally given Xuebijing injection. The white blood cell count (WBC),C-creation protein (CRP) and procalcitonin (PCT),liver and kidney function and hospitalization time before and after treatment were collected and adverse reaction. RESULTS:The WBC in experimental group af-ter 3 and 6 d of treatment was respectively(13.6±3.4)×109 L-1 and(9.1±4.2)×109 L-1,CRP was respectively(52.7±13.6)mg/L and(8.5±3.3)mg/L,the PCT(0.3±0.2)ng/ml,and the hospitalization time after 3 d were lower than control group,with signifi-cant difference(P<0.05). There were no significant difference in the liver and kidney function(P>0.05). There was 1 case with itch of skin but with no severe ADR. CONCLUSIONS:Xuebijing injection in the adjuvant treatment of children with perforated ap-pendicitis is safe and effective.
