Clinical Observation of Spraying Mannatide and 5-fluorouracil in Anocelia during Surgery of Lung Cancer
10.6039/j.issn.1001-0408.2015.18.08
- VernacularTitle:肺癌术中胸腔喷洒甘露聚糖肽和5-氟尿嘧啶的临床观察
- Author:
Zheng MA
;
Jianjun LI
;
Ping REN
;
Fangchao GONG
;
Youbin CUI
- Publication Type:Journal Article
- Keywords:
Lung cancer radical surgery;
Mannatide;
5-fluorouracil;
Toxicity;
Immune function;
Survival rate;
Recurrence rate
- From:
China Pharmacy
2015;(18):2473-2475
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy and safety of spraying mannatide and 5-fluorouracil in anocelia during sur-gery of lung cancer based on the adjuvant chemotherapy. METHODS:Totally 114 patients with lung cancer radical surgery were randomly divided into observation group(59 cases)and control group(55 cases). There were spraying mannatide(40-80 mg)and 5-fluorouracil(500 mg)in the observation group;and nothing drugs were sprayed in control group. The patients higher than phaseⅡ were treated by adjuvant chemotherapy after surgery for continuous 2 cycles,21 d as a cycle. The clinical data was compared, including amount of bleeding and drainage,hospital stay,complications,toxicity,KPS score,body weight changes,immune func-tion,survival rate and recurrence rates between 2 groups. RESULTS:There were no significant differences among the amount of bleeding and drainage,hospital stay and complications in the 2 groups (P>0.05). The nausea,vomiting,leucopenia,the KPS score,improvement of total effective rate,and improvement rate of body mass,immune function,survival rate in 1 and 2 year (s),recurrence rate and time within 2 years in observation group were significantly better than control group,with significant dif-ferences(P<0.01 or P<0.05). CONCLUSIONS:Spraying mannatide and 5-fluorouracil can reduce the toxicity in anocelia during surgery of lung cancer based on the adjuvant chemotherapy,improve the immune function and survival rate,reduce recurrence rate and prolong the recurrence time.
