Clinical Observation of Shenfu Injection Combined with Danshen Chuanxiongqin Injection in the Treatment of Chronic Pulmonary Heart Disease Patients with Heart Failure
10.6039/j.issn.1001-0408.2015.18.12
- VernacularTitle:参附注射液联合丹参川芎嗪注射液治疗慢性肺源性心脏病心力衰竭的临床观察
- Author:
Longjun JIANG
;
Jianxin WU
;
Rongjun ZHAO
;
Yiming ZHANG
- Publication Type:Journal Article
- Keywords:
Shenfu injection;
Danshen chuanxiongqin injection;
Chronic pulmonary heart disease;
Heart failure;
Efficacy;
Safety
- From:
China Pharmacy
2015;(18):2483-2485
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the clinical efficacy and safety of Shenfu injection combined with Danshen chuanxiongqin injection in the treatment of chronic pulmonary heart disease patients with heart failure. METHODS:Totally 100 chronic pulmonary heart disease patients with heart failure were randomly divided into observation group and control group. Patients in control group were given routine treatment,including antispasmodic asthma,low-flow oxygen therapy,anti-inflammatory,diuretic strong heart, maintaining the body water,electrolyte balance,vasoactive drugs and dopamine,etc. Patients in observation group were given Shenfu injection 50 ml and Danshen chuanxiongqin injection 10 ml adding into 5% glucose injection 250 ml based on the treatment of control group,iv,once a day. The course of both was 14 d. The clinical data was observed,including clinical efficacy,improve-ment time of signs and symptoms,p(O2),p(CO2),SV,LVEF,LVEDD,LVSD and the incidence of adverse reactions before and after treatment. RESULTS:The total effective rate in observation group was significantly higher than control group,the remission time of cyanosis,slowing time of heart rate and subsided time of swelling were significantly shorter than control group,with signif-icant differences(P<0.05). After treatment,the p(O2),p(CO2),SV,LVEF,LVEDD and LVSD in 2 groups were significantly bet-ter than before,and observation group was better than control group,with significant differences(P<0.05). There were no obvious adverse reactions during treatment. CONCLUSIONS:Based on the treatment,Shenfu injection combined with Danshen chuanxion-gqin injection has better clinical efficacy than routine treatment in the treatment of chronic pulmonary heart disease patients with heart failure,with similar safety.
