Comparative Study of Only Paroxetine and Paroxetine Combined with Alprazolam in the Treatment of Diabe-tes Complicated with Anxiety and Depression
10.6039/j.issn.1001-0408.2015.18.17
- VernacularTitle:帕罗西汀单用及与阿普唑仑联用治疗糖尿病合并焦虑抑郁的对照研究
- Author:
Pang JIN
;
Tao CHENG
;
Jing CHEN
- Publication Type:Journal Article
- Keywords:
Paroxetine;
Alprazolam;
Diabetes;
Anxiety;
Depression;
Efficacy;
Safety
- From:
China Pharmacy
2015;(18):2495-2497
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the efficacy and safety of only paroxetine vs. paroxetine combined with alprazolam in the treatment of diabetes complicated with anxiety and depression. METHODS:Totally 86 patients with diabetes complicated with anxi-ety and depression were randomly divided into observation group and control group. The patients in observation group were given paroxetine 20 mg,qd,and alprazolam 0.4 mg,tid;patients in control group were given paroxetine alone. The treatment course lasted for 8 weeks in 2 groups. The clinical data was compared,including fasting plasma glucose(FPG),2 h postprandial glucose (2 h PG),glycated hemoglobin (HbA1c),cortisol,adrenocorticotropic hormone (ACTH) levels and scores of Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD). The adverse reactions were observed. RESULTS:After treatment,FP-BG,2 h PG,HbA1c,cortisol,ACTH levels and scores of HAMA and HAMD in observation group were significantly lower than control group,with significant difference(P<0.05). There were significant differences in the incidence of adverse reactions be-tween 2 groups(P>0.05). CONCLUSIONS:Compared with paroxetine alone,paroxetine combined with alprazolam can improve more in blood glucose,endocrine levels and adverse mood symptoms in the treatment of diabetes complicated with anxiety and de-pression,with similar safety.
