Clinical Analysis of Drug Fever Induced by Piperacillin Sodium and Tazobactam Sodium for Injection
10.6039/j.issn.1001-0408.2015.18.20
- VernacularTitle:注射用哌拉西林钠他唑巴坦钠致药物热的临床分析
- Author:
Xin ZHENG
;
Mei LU
- Publication Type:Journal Article
- Keywords:
Piperacillin sodium and tazobactam sodium for injection;
Drug fever;
Adverse drug reaction
- From:
China Pharmacy
2015;(18):2503-2505
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To provide reference for the timely and accurate judgment of drug fever induced by Piperacillin sodi-um and tazobactam sodium for injection and rational drug use in the clinic. METHODS:The medication,clinical manifestations, laboratory examination results and the physician treatment of 30 inpatients with drug fever induced by Piperacillin sodium and tazo-bactam sodium for injection from Sept. 2013 to Sept. 2014 were analyzed retrospectively and statistically. RESULTS:Most of the drug fever induced by Piperacillin sodium and tazobactam sodium for injection occurred in continuous 7 to 14 d medication,and the cumulative dosages were between 1.3 to 2.7 g/kg;73.3% of the 30 patients had fever during the intravenous drip,with body temperature mainly≥38.5 ℃;the elevation of eosinophil and slightly increase of serum C-reactive protein (CRP) and blood cell sedimentation rate (ESR) could be used as observation indexes of drug fever,but the leucocyte reduce could’t be suitable;the body temperature dropped to normal within 24 to 48 hours after stopped using it. CONCLUSIONS:The drug fever induced by Piperacillin sodium and tazobactam sodium for injection has no correlation with the patients’gender or age,and no special diagnos-tic criteria. But it has certain correlation with duration of medication,cumulative days and dosages and it can be used as reference of judgment with the combination of hematological examination index. Clinicians should improve the understanding and attention about drug fever to stop using suspicious drug in time.
