Adsorbability Study of Plastic Transfusion Bottle and Infusion Set to Diazepam
10.6039/j.issn.1001-0408.2015.18.41
- VernacularTitle:塑料输液瓶和输液器对地西泮的吸附性考察
- Author:
Qingrong XIA
;
Jun LIANG
;
Yin CAO
- Publication Type:Journal Article
- Keywords:
Plastic infusion bottle;
Disposable plastic infusion set;
Diazepam;
Adsorbability;
HPLC
- From:
China Pharmacy
2015;(18):2564-2566
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the adsorbability of plastic transfusion bottle and infusion set to diazepam. METHODS:With the reference of plastic-bottled 5% glucose injection,HPLC was used to determine the changes of mass concentration of diazepam adding into plastic-bottled 5% glucose injection at different time;disposable plastic infusion set was connected to simulate intrave-nous infusion and determine the changes of mass concentration of diazepam in the liquid effluent at different time. RESULTS:The mass concentration of diazepam in glass infusion bottles group was higher than in plastic transfusion bottles group. The adsorbabili-ties of solutions showed the strongest at the time of 15-20 min. The mass concentration of the effluent liquid from the glass bottle group was about 80% of the original concentration and plastic bottle group was about 67%. As the time went on,the adsorbability was gradually saturated at 60 min and the concentration rose again;the mass concentration of the effluent liquid from the glass bot-tle group returned to 95%of the original concentration at 80 min and the plastic bottle group was about 75%of the original concen-tration. CONCLUSIONS:Both plastic infusion bottle and infusion set have strong adsorbability to diazepam. It is suggested that the dosage of diazepam should be increased by 25% to 33% while plastic-bottled 5% glucose injection is used as solvent for intrave-nous drip.
