Study on the Quality Standard of Fructus arctii Concentrated Granules
10.6039/j.issn.1001-0408.2015.18.29
- VernacularTitle:牛蒡子配方颗粒的质量标准研究
- Author:
Lanmin ZHEN
;
Junshan LI
;
Hai JIANG
;
Zhong CHEN
;
Zhenjiang LI
- Publication Type:Journal Article
- Keywords:
Fructus arctii;
Concentrated granules;
TLC;
HPLC;
Quality standard
- From:
China Pharmacy
2015;(18):2532-2534
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish the quality standard of Fructus arctii concentrated granules. METHODS:TLC was con-ducted for the qualitative identification and HPLC was used for the content determination of arctiin in F. arctii concentrated gran-ules. The determination was performed on Dionex C18 column with mobile phase consisted of methanol-water(40∶60,V/V) at the flow rate of 1.0 ml/min. The detection wavelength was set at 280 nm,and the column temperature was 30 ℃. The samples size was 10 μl. RESULTS:TLC spectrum showed that the spots of F. arctii concentrated granules and arctiin reference medicinal material had the same color;the linear range of arctiin was 0.5-12.5 μg(r=0.999 8)with the average recovery of 98.41%(RSD=0.81%, n=9). The RSDs of precision,stability,repeatability tests were no more than 1.0%. CONCLUSIONS:The method is feasible and reproducible,and can effectively control the quality of F. arctii concentrated granules.
