Study on the Quality Standard of Qiqilian Capsule
10.6039/j.issn.1001-0408.2015.33.34
- VernacularTitle:芪七连胶囊的质量标准研究
- Author:
Yuan LUO
;
Yun YE
;
Guihua YUE
;
Jianqin LIANG
- Publication Type:Journal Article
- Keywords:
Qiqilian capsule;
Quality standard;
TLC;
HPLC;
Ginsenosides;
Notogisenosides
- From:
China Pharmacy
2015;26(33):4706-4708
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish the quality standards for Qiqilian capsule. METHODS:TLC was used to identify the As-tragali Radix,Phellodendri chinensis,Coptidis rhizom. HPLC was used to determine the contents of ginsenosides Rg1,ginsenosides Rb1 and notoginsenosides R1. The column was Shim-pack VP-ODS C18 with mobile phase of acetonitrile-water(gradient elution) at flow rate of 1.0 ml/min,detection wavelength was 203 nm,column temperature was 20 ℃. RESULTS:TLC of Astragali Radix,P. chinensis,C. rhizom showed cleer sports and good separation. The linear range was 0.9-9.0 μg for ginsenosides Rg1,0.94-9.4 μg for ginsenosides Rb1 and 0.3-3.0 μg for notoginsenosides R1(r≥0.999 5);RSDs of precision,reproducibility and stability test were lower than 3.0%;recoveries were 96.08%-99.75%(RSD=1.52,n=6),97.03%-99.75%(RSD=1.10,n=6)and 96.38%-98.55%(RSD=0.90,n=6),respectively. CONCLUSIONS:The method is simple,good reproducibility,and can be used for the quality control of Qiqilian capsule.
