Observation on the Effect of Cefotaxime with Different Doses in Periopration Period on the Prevention of Postoperative Infection of Lung Cancer Resection
10.6039/j.issn.1001-0408.2015.33.17
- VernacularTitle:肺癌根治术围术期使用不同剂量头孢噻肟预防术后感染的效果观察
- Author:
Xiaolong HUANG
;
Xiaofang ZHOU
;
Zeng WANG
;
Jianchao WANG
- Publication Type:Journal Article
- Keywords:
Lung cancer;
Perioperative period;
Cefotaxime;
Different doses;
Postoperative infection
- From:
China Pharmacy
2015;26(33):4655-4657
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effecacy and safety of using cefotaxime using different doses in perioprative period on the prevention of postoperative infection of lung cancer resection. METHODS:61 patients with non-small cell lung cancer who re-ceived lung cancer resection were retrospectively analyzed divided into cefotaxime 2 g group(26 cases) and cefotaxime 4 g group (35 cases)according to dosage. Cefotaxime 2 g group was treated with Cefotaxime for injetion 2 g 30 min before operation,add-ing into 0.9% sodium chloride injection 100 ml,by intravenous infusion,if the operation time was more than 3 h,cefotaxime 2 g was intravenously infused during operation and cefotaxime 2 g was intravenously infused after operation,interval of 12 h was re-quired for preoperative and postoperative medication time and the total medication time was no more than 48 h. Cefotaxime 4 g group was treated with Cefotaxime for injection 4 g(the usage was the same as cefotaxime 2 g group). Leukocyte,hemoglobin,al-bumin,infection rate and incidence of adverse reactions in 2 groups before and after operation were observed. RESULTS:There was no significant difference in the infection rates between 2 groups(P>0.05). Leukocyte,hemoglobin and albumin in 2 groups were significantly lower than before,the differences were statistically significant(P<0.05),however,there was no significant dif-ference between 2 groups(P>0.05). There were no obvious adverse reactions during treatment. CONCLUSIONS:Small dose of ce-fotaxime has good prevention effect on the postoperative infection of non-small cell lung cancer,with good safety,which meets the principles of rational use of antibiotics.
