Clinical Observation of Metformin in the Treatment of Type 2 Diabetes with Non-alcoholic Fatty Liver Disease
10.6039/j.issn.1001-0408.2015.33.19
- VernacularTitle:二甲双胍治疗2型糖尿病合并非酒精性脂肪肝病的临床观察
- Author:
Yong RUAN
;
Qingying TAN
;
Yun RUAN
;
Xiujing WANG
;
Jiaqi YAO
;
Huiling WANG
;
Jing WANG
- Publication Type:Journal Article
- Keywords:
Metformin;
Type 2 diabetes;
Non-alcoholic fatty liver;
Efficacy;
Safety
- From:
China Pharmacy
2015;26(33):4659-4661
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy and safety of metformin in the treatment of type 2 diabetes(T2DM) with non-alcoholic fatty liver disease(NAFLD). METHODS:106 patients with T2DM with NAFLD were randomly divided into control group and observation group. Control group was received health education about T2DM with NAFLD and living intervention(diabe-tes diet and physical therapy);observation group was additionally given Metformin tablet 0.5 g,orally,3 times a day. The treat-ment course for both groups was 12 weeks. Clinical efficacy,and liver fat content,BMI,FPG,IR,TG,TC,LDL-C,HDL-C,HbA1c before and after treatment,and incidence of adverse reactions in 2 groups were observed. RESULTS:After treatment,liver fat con-tent and related index in 2 groups were significantly better than before(except HOMA-IR in control group),and observaton group was better than control group,the differences were statistically significant(P<0.05). The total effective rate in observation group was significantly higher than control group,the difference was statistically significant(P<0.05). CONCLUSIONS:Based on the conventional treatment,metformin has good efficacy and safety in the treatment of T2DM with NAFLD.
