Effects of Folic Acid Combined with Vitamin B12 on Related Indicators of Patients with Hypertension,Cere-bral Stroke and Vascular Cognitive Impairment
10.6039/j.issn.1001-0408.2015.33.20
- VernacularTitle:叶酸联合维生素B12对高血压合并脑卒中伴轻度认知障碍患者相关指标的影响
- Author:
Fen ZHANG
;
Hongying MA
;
Xiuting GUO
;
Ge ZHANG
- Publication Type:Journal Article
- Keywords:
Hypertension;
Cerebral stroke;
Cognitive impairment;
Folic acid;
Vitamin B12;
Homocysteine
- From:
China Pharmacy
2015;26(33):4661-4663
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the effects of folic acid combined with vitamin B12 on the vascular cognitive impairment (VCI)and homocysteine(Hcy)of patients with hypertension and cerebral stroke. METHODS:80 VCI patients with hypertension and cerebral stroke were regarded as observation group,and another 20 healthy volunteers were regarded as healthy control group. Observation group was treated with enhanced homogenized meal 300-500 ml,3 times a day+Folic acid tablet 5 mg,3 times a day+Vitamin B12 tablet 25 μg,3 times a day. Observation groups were treated for continuous 2 months with no nasal administration by themselves. The Mini-Mental State Examination(MMSE)score,the level of folic acid,vitamin B12 and Hcy before and after treat-ment were observed and compared with healthy control group,and the incidence of adverse reactions was recorded. RESULTS:Af-ter treatment,MMSE score,the level of folic acid,vitamin B12 in observation group were significantly higher than before and low-er than healthy control group,the level of Hcy was significantly lower than before and higher than healthy control group,the differ-ences were statistically significant(P<0.05). The incidence of adverse reactions was 5.00%. There were no serious adverse reac-tions. CONCLUSIONS:Folic acid combined with vitamin B12 can reduce the cognitive impairment degree of patients with hyperten-sion,cerebral stroke and vascular cognitive impairment and level of Hcy,with good safety.
