Clinical Observation of Vitamin B12 Combined with Mouse Nerve Growth Factor in the Treatment of Neuro-genic Tinnitus
10.6039/j.issn.1001-0408.2015.33.18
- VernacularTitle:维生素B12联合鼠神经生长因子治疗神经性耳鸣的临床观察
- Author:
Min MAO
;
Gang LEI
- Publication Type:Journal Article
- Keywords:
Vitamin B12;
Mouse nerve growth factor;
Neurogenic tinnitus;
Efficacy;
Safety
- From:
China Pharmacy
2015;26(33):4657-4659
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the efficacy and safety of vitamin B12 combined with mouse nerve growth factor in the treatment of neurogenic tinnitus. METHODS:270 patients with neurogenic tinnitus were randomly divided into control group 1, control group 2 and observation group. Control group 1 was treated with Vitamin B12 injection 25 μg by intramuscular injection, once a day;control group 2 was treated with mouse nerve growth factor 18 μg adding into 2 ml water for injection for dissolution, once a day;observation group was treated with Vitamin B12 injection 25 μg(the usage was the same as control group 1)+mouse nerve growth factor 18 μg(the usage was the same as control group 2). 6 d was a treatment course,and it lasted 2 courses. Clinical efficacy,and sleep SPIEGEL score and incidence of adverse reactions before and after treatment in 3 groups were observed. RE-SULTS:Total effective rate in observation group was significantly higher than control group 1 and control group 2,the difference was statistically significant (P<0.05);however,there was no significant difference between control group 1 and control group 2 (P>0.05). After treatment,sleep SPIEGEL score in 3 groups was significantly higher than before,and observation group was high-er than control group 1 and control group 2,the difference was statistically significant(P<0.05);however,there was no signifi-cant difference between control group 1 and control group 2(P>0.05). There were no obvious adverse reactions during treatment. CONCLUSIONS:Vitamin B12 combined with mouse nerve growth factor has better efficacy than only vitamin B12 or mouse nerve growth factor in the treatment of neurogenic tinnitus,with good safety.
