Clinical Observation of Prucalopride in the Treatment of Functional Constipation
10.6039/j.issn.1001-0408.2015.20.25
- VernacularTitle:普芦卡必利治疗功能性便秘的临床观察
- Author:
Jing ZHENG
;
Sai GU
- Publication Type:Journal Article
- Keywords:
Functional constipation;
Prucalopride;
Clinical efficacy;
Safety
- From:
China Pharmacy
2015;(20):2808-2810
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the clinical efficacy and safety of prucalopride in the treatment of functional constipation (FC). METHODS:In prospective self-controlled study,87 female patients with FC were selected and given prucalopride 2 mg,1 time per day. The total course was four weeks. The defecate frequency,stool property and constipation symptom grade were ob-served before and after treatment. Related adverse drug reaction were observed during treatment. RESULTS:During the period of treatment,the defecate frequency was gradually increased,the stool property was gradually improved,and the constipation symp-tom grade of the patients was also improved. The difference had statistical significance before and after treatment(P<0.01). No sig-nificant adverse drug reaction was found during the study. CONCLUSIONS:Prucalopride is a safe and effective treatment for pa-tients with FC.
