Study on the Compatible Stability of Amphotericin B for Injection and 5%Glucose Injection from Different Manufacturers

VernacularTitle:注射用两性霉素B与不同厂家5％葡萄糖注射液的配伍稳定性考察Δ
Author: Rong LIU ; Xialin LU ; Ping DONG
Publication Type:Journal Article
Keywords: Amphotericin B; Glucose injection; Compatibility; Stability
From: China Pharmacy 2015;(20):2771-2773
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To study the factors affecting the compatible stability of amphotericin B(AmB)and 5%glucose injec-tion from different manufacturers,and to provide reliable evidence for the selection of solvent carrier of AmB. METHODS:After the combination of AmB and 5%glucose injection from different manufacturers(manafactarer A,B,C,D,E),it was shielded from light with room temperature(25℃)for 0,1,2,4,6 and 8 h. HPLC was conducted to determine the content changes of AmB in samples and observe the character,clarity and pH values. RESULTS:With the prolonging of time,insoluble impurities were detected in AmB and 5%glucose injection with the pH value less than 4.2 and the content of main drugs was decreased. Only 5%glucose injection from manufacturer A was in line with the requirements of AmB compatibility. CONCLUSIONS:The compatible stability of AmB and 5%glucose injection is closely related to pH values. It is suggested that manufacturers of infusions make clear descriptions of the pH value to select suitable infusions and safe drugs.