Effect of Maren Pills Combined with Lactulose Preventing Opioid-induced Constipation in Cancer Pain Pa-tients
10.6039/j.issn.1001-0408.2015.20.34
- VernacularTitle:麻仁丸联合乳果糖对癌痛患者阿片诱导性便秘的预防作用
- Author:
Jun XUE
;
Daokun WANG
;
Jingyu LIU
;
Ting ZHU
;
Meilin CHEN
;
Wenjuan LI
- Publication Type:Journal Article
- Keywords:
Maren pills;
Lactulose;
Drug combination;
Opioid-induced constipation;
Constipation score
- From:
China Pharmacy
2015;(20):2835-2837
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effect of Maren pills combined with lactulose preventing opioid-induced constipation (OIC) in patients with cancer pain. METHODS:281 cases of advanced cancer pain were selected and divided into Maren pills group,lactulose group and drug combination group. 3 groups were given opioid to relieve pain,and additionally received Maren pills,lactulose or drug combination(lactulose for 3 d and then Maren pills for 3 d instead,repeated in the same way)to treatment OIC prophylactically. The constipation conditions of 3 groups were observed and recorded at 2,4 and 6 weeks after the therapy. And then the data were analyzed statistically. RESULTS:The regular doses of Maren pills and lactulose alone or combination had prevention effect on OIC. Drug combination showed better long-term prevention effect;there were statistically significant difference in constipation conditions between grug combination group and other 2 groups after 4 and 6 weeks of therapy (P<0.05 or P<0.01). CONCLUSIONS:Maren pills combined with lactulose are obvious benefit for constipation prevention and relief in cancer pain patients who use opioid for a long time.
