Clinical Observation of Mirabilite Combined with Cisplatin Intraperitoneal in the Treatment of Elderly Colorectal Malignant Ascites

VernacularTitle:芒硝外敷联合顺铂腹腔灌注治疗老年结直肠癌恶性腹水的临床观察
Author: Yuan ZHOU ; Honggang JIANG ; Bohao LU ; Zhiheng CHEN
Publication Type:Journal Article
Keywords: Mirabilite for external use; Intraperitoneal; Elderly; Malignant ascites
From: China Pharmacy 2015;(20):2840-2842
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To observe the clinical efficacy and ADR of Mirabilite combined with intrapetitoneal in the treatment of elderly colorectal malignant ascites. METHODS:77 cases of patients with elderly colorectal malignant ascites were randomly di-vided into treatment group (n=40) and control group (n=37). The control group received the treatment of intraperitoneal alone, while the treatment group was based on the control group additionally received Mirabilite combined with intrapetitoneal. The clini-cal efficacy,quality of life (QOL),and ADR in 2 groups were compared and statistically analyzed. RESULTS:Compared with control group,the effective rate in treatment group was 77.5% and the disease control rate was 87.5%,with significant difference (P<0.05);the QOL score in treatment group was better than control group,with significant difference(P<0.05);the incidence of local ADR in Mirabilite for external use was low. CONCLUSIONS:Mirabilite combined with intraperitoneal has better efficacy in the elderly colorectal malignant ascites and better QOL.