Comparative Study on the Efficacy and Safety of Kangshuling Gel,Mupirocin and Lactate Ethacridine for Diabetic Foot
10.6039/j.issn.1001-0408.2015.21.06
- VernacularTitle:慷舒灵凝胶、莫匹罗星或乳酸依沙吖啶治疗糖尿病足的疗效与安全性比较Δ
- Author:
Guilin LIANG
;
Lu LIU
;
Zhankui LIU
;
Xin XU
- Publication Type:Journal Article
- Keywords:
Diabetic foot;
Kangshuling gel;
Mupirocin;
Lactate ethacridine
- From:
China Pharmacy
2015;(21):2896-2898
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the clinical efficacy and safety of Kangshuling gel,mupirocin and lactate ethacridine in the treatment of diabetic foot. METHODS:90 patients with diabetic foot were randomly divided into Kangshuling group,mupiro-cin group and lactate ethacridine group. All the patients were treated by lowing blood glucose,nutritional support,improving micro-circulation and anti-infection,etc. On this basis,3 groups were given Kangshuling gel,Mupirocin ointment and Lactate ethacridine solution for wet compress by gauze. The course was 180 d. The clinic data was observed,including clinical efficacy,and wound ar-ea,healed patients’granulation,epithelial tissue,healing time and incidence of adverse reactions before and after treatment. RE-SULTS:The total effective rate in Kangshuling group was significantly higher than mupirocin group and lactate ethacridine group;healed patients’granulation,epithelial tissue and healing time were significantly shorter than mupirocin group and lactate ethacri-dine group,with significant differences(P<0.05). After treatment,wound area in each group were significantly smaller than be-fore,and Kangshuling group was smaller than mupirocin group and lactate ethacridine group,with significant differences(P<0.05);there were no significant differences between mupirocin group and lactate ethacridine group(P>0.05). There were no obvi-ous adverse reactions during treatment. CONCLUSIONS:Based on the conventional treatment,Kangshuling gel has better efficacy than mupirocin and lactate ethacridine in the treatment of diabetic foot,with good safety.
