Clinical Observation of Small-dose Argatroban vs. Aspirin in the Treatment of Acute Cerebral Infarction
10.6039/j.issn.1001-0408.2015.21.20
- VernacularTitle:小剂量阿加曲班对比阿司匹林治疗急性脑梗死的临床观察
- Author:
Yunfeng FAN
- Publication Type:Journal Article
- Keywords:
Argatroban;
Aspirin;
Acute cerebral infarction;
Recurrence rate;
Nerve function
- From:
China Pharmacy
2015;(21):2933-2935
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effect and safety of small-dose argatroban vs. aspirin in the treatment of acute cerebral infarction. METHODS:136 patients with acute cerebral infarction were randomly divided into observation group and control group. All patients were given routine treatment,such as anti-intracranial pressure,oxidative stress,brain protection,oxygen,blood pres-sure,blood sugar control,anti-infective,water and electrolyte acid-base balance,etc. Based on it,control group was treated with Arginine aspirin for injection 100 mg,adding into 0.9% Sodium chloride injection 250 ml,iv,once a day. Observation group was treated with Argatroban injection 40 mg,adding into 0.9% Sodium chloride injection 500 ml,24 h continuous infusion for continu-ous 2 d,iv;then dose was decreased to 10 mg,adding into 0.9% Sodium chloride injection 100 ml,iv,once a day,for continu-ous 5 d. The course of both was 7 d. The clinic data was observed,including clinical efficacy,NIHSS(National Institutes of Health Stroke Scale)score,Bathel index scores before and after treatment,and incidence of adverse reactions. The recurrence rate of cere-bral infraction during the 2-year follow-up period was observed. RESULTS:The total effective rate in observation group was signifi-cantly higher than control group,the recurrence rates of cerebral infarction in observation group within 1 and 2 year(s)were signifi-cantly lower than control group,with significant difference(P<0.05). After treatment,the NIHSS score in 2 groups were signifi-cantly lower than before,observation group was lower than control group;Bathel score was significantly higher than before,and observation group was higher than control group,with significant differences(P<0.05). There were no significant differences in the incidence of adverse reactions between 2 groups(P>0.05). CONCLUSIONS:Based on the conventional treatment,compared with aspirin, small-dose argatroban can significantly commute the nerve function of acute cerebral infarction,and reduce the recurrence rate of cerebral infarction,with good safety.
