Effect of Cinepazide Maleate Combined with Xueshuantong Injection on the Blood Supply of Subcutaneous Artery after Flap Transplantation
10.6039/j.issn.1001-0408.2015.21.24
- VernacularTitle:马来酸桂哌齐特联合血栓通注射液对皮瓣移植术后皮下动脉供血效果的影响
- Author:
Zhiting FENG
;
Sicang CHEN
;
Wuqi WANG
- Publication Type:Journal Article
- Keywords:
Cinepazide maleate;
Xueshuantong injection;
Flap transplantation;
Subcutaneous artery;
Blood supply
- From:
China Pharmacy
2015;(21):2944-2946
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the effect of cinepazide maleate combined with Xueshuantong injection on the blood sup-ply of subcutaneous artery after flap transplantation. METHODS:68 patients with cross-regional combined with flap transplantation in extremity soft tissue injury were randomly divided into observation group and control group. The roast lamp irradiation in the flap transplantation and ambulation prohibited,alcohol and tobacco prohibited were carried out as rountine treatment. On this basis, control group was treated with cephalosporins,papaverine and low molecular dextran after flap transplantation. Observation group was treated with cinepazide maleate 8 ml adding into 0.9% Sodium chloride injection 250 ml by intravenous infusion,once a day+Xueshuantong injection 5 ml adding into 0.9% Sodium chloride injection 250 ml by intravenous infusion,once a day. The course for both was 14 d. The clinic data was observed,including blood rheological indicators (whole blood high cut,whole blood cut, whole blood low cut,plasma viscosity and RBC aggregation index),and coagulation function indicators [thrombin time(TT),acti-vated partial thromboplastin time(APTT),prothrombin time(PT)and GB normalized ratio(INR)] before and after 1,3 and 7 d of surgery,and the postoperative incidence of arterial vascular crisis within 7 d and adverse reactions. RESULTS:There was no sig-nificant difference in the incidence of arterial vascular crisis in 2 groups after 1 and 2 d of surgery(P>0.05);the incidence of arte-rial vascular crisis in 3,4,5,6 and 7 d in observation group was significantly lower than control group,with significant difference (P<0.05). After 3 and 7 d of surgery,blood rheological indicators and 1,3 and 7 d of coagulation function indicators in 2 groups were significantly better than before,and observation group was better than control group,with significant difference(P<0.05). There were no significant difference in the incidence of adverse reactions between 2 groups(P>0.05). CONCLUSIONS:Cinepa-zide maleate combined with Xueshuantong injection can effectively improve the blood rheological indicators and coagulation func-tion indicators of patients,reduce the incidence of arterial vascular crisis,with good safety.
