Analysis of the Bacterial Resistance and Use of Vancomycin in 202 Cases of Neonatal Sepsis in Our Hospital

VernacularTitle:我院202例新生儿败血症病例细菌耐药性及万古霉素应用情况分析Δ
Author: Jing ZHAO ; Rui FENG ; Jie DU
Publication Type:Journal Article
Keywords: Neonatal sepsis; Bacterial resistance; Vancomycin
From: China Pharmacy 2015;(21):2901-2903
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To provide reference for the rational use of vancomycin in neonatal sepsis. METHODS:A retrospec-tive survey was performed for newborns with neonatal sepsis in our hospital from Sept. 1st in 2011 to Sept. 1st in 2012,and the pathogenic examination results,bacterial resistance and use of vancomycin were analyzed and summarized. RESULTS:Totally 317 strains of pathogens were detected in 202 cases,including 147 strains of G+ bacteria(46.4%),88 strains of fungus(27.7%)and 82 strains of G- bacteria (25.9%). Coagulase-negative staphylococcus was the main pathogens. The use rate of vancomycin was 47.0%(95 cases),and the drug selections were all based on susceptibility,with most of two-drug combination(68 cases). No se-vere adverse reactions were found. CONCLUSIONS:Coagulase-negative staphylococcus is severe and has multi-drug resistance in the cases of neonatal sepsis in our hospital. While,the use of vancomycin is basically rational. However,the clinical use of vanco-mycin should be more cautious to prevent the generation of vancomycin-resistant strains.