Clinical Observation of Sodium Hyaluronate Combined with Glucosamine in the Treatment of Knee Osteoar-thritis
10.6039/j.issn.1001-0408.2015.21.23
- VernacularTitle:玻璃酸钠联合氨基葡萄糖治疗膝关节骨性关节炎的临床观察
- Author:
Meijuan XU
;
Xianli FENG
;
Shibang LIN
- Publication Type:Journal Article
- Keywords:
Sodium hyaluronate;
Glucosamine;
Knee;
Osteoarthritis
- From:
China Pharmacy
2015;(21):2941-2943
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the clinical efficacy and safety of sodium hyaluronate combined with glucosamine in the treatment of knee osteoarthritis. METHODS:1 220 patients with knee osteoarthritis were randomly divided into observation group and control group. The patients in control group were treated with Sodium hyaluronate injection alone,once a week;while the ob-servation group was additionally and orally treated with Glucosamine hydrochloride capsules two tablets,three times a day. The course of treatment was 5 weeks in both groups. The relevant physicotherapeutics and oral medication in the treatment of the dis-ease should be stopped. The clinic efficacy,visual analog scale(VAS)and lysholm knee score before and after treatment,and inci-dence of adverse reaction were observed. RESULTS:Total effective rate of observation group was significantly higher than control group,with statistically significant difference(P<0.05). After treatment,VAS and lysholm knee scores in both groups were signifi-cantly lower than before,and observation group was lower than control group,with significant differences(P<0.05). There were no severe adverse reactions during treatment. CONCLUSIONS:Sodium hyaluronate combined with glucosamine has more signifi-cant clinical efficacy in the treatment of knee osteoarthritis than sodium hyaluronate alone,with good safety.
