Study on Bacterial Endotoxin Test of Vinpocetine Raw Material
10.6039/j.issn.1001-0408.2015.21.43
- VernacularTitle:长春西汀原料药细菌内毒素检查法研究
- Author:
Jichun ZHOU
- Publication Type:Journal Article
- Keywords:
Vinpocetine raw material;
Bacterial endotoxin;
Tachypleus amebocyte lysate;
Interference test
- From:
China Pharmacy
2015;(21):2999-3000
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish a method for the bacterial endotoxin test of vinpocetine raw material. METHODS:Ac-cording to the bacterial endotoxin test in the Chinese Pharmacopoeia(2010 edition,Ⅱ)Appendix Ⅺ E,the samples with different batches were used for interference test and bacterial endotoxin test by tachypleus amebocyte lysate from 2 manufacturers. RE-SULTS:The vinpocetine solutions with high concentration have interference effect on the agglutination reaction of bacterial endotox-in and the interference can be eliminated by diluting. CONCLUSIONS:The non-interference concentration of vinpocetine solutions is 0.25 mg/ml. Bacterial endotoxin test can be used to control the quality.
