The significance of procalcitonin and C-reactive protein in the early diagnosis of sepsis after percutaneous nephrolithotomy
10.3760/cma.j.jssn.1673-4904.2016.10.013
- VernacularTitle:探讨降钙素原和C反应蛋白对经皮肾镜取石术后发生脓毒症的早期诊断意义
- Author:
Zengli WANG
;
Weihong ZHAO
;
Wuqi SUN
;
Yongwei LI
- Publication Type:Journal Article
- Keywords:
Calcitonin;
C- reactive protein;
Sepsis;
Nephrostomy,percutaneous;
Early diagnosis;
Retrospective studies
- From:
Chinese Journal of Postgraduates of Medicine
2016;39(10):904-907
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of procalcitonin (PCT) and C-reactive protein (CRP) in the early diagnosis of sepsis in patients with percutaneous nephrolithotomy (PCNL). Methods One hundred and ninety-eight patients who had underwent PCNL were divided into sepsis group (148 cases) and control group (50 cases). The PCT and CRP 6 h before and after operation were compared between 2 groups, and the receiver operating characteristic curve was drawn. The area under curve (AUC), optimal diagnostic boundary value, susceptibility and specificity were calculated. Results The PCT and CRP before operation in sepsis group were significantly higher than those in control group:(3.911 ± 2.011) ng/L vs. (1.353 ± 0.311) ng/L and (54.85 ± 8.75) g/L vs. (38.65 ± 10.76) g/L, and there were statistical differences (P<0.01). The AUC of PCT was 0.974, and the AUC of CRP was 0.853. The optimal diagnostic boundary value of PCT was > 1.65 ng/L, and the susceptibility and specificity were 97.91% and 91.01%; the optimal diagnostic boundary value of CRP was > 43.54 g/L, and the susceptibility and specificity group were 93.51% and 79.21%. Conclusions For patients with sepsis after PCNL, PCT is more significant than CRP for early diagnosis. PCT detection can be used as an important auxiliary examination for clinical diagnosis of sepsis, which could help clinicians to detect and treat the sepsis early and can greatly improve the survival rate of patients.
