An observation on curative effect of large dose of rhubarb and mirabilite for treatment of patients with acute pancreatitis
10.3969/j.issn.1008-9691.2016.05.008
- VernacularTitle:重用生大黄和芒硝治疗急性胰腺炎的疗效观察
- Author:
Yu GOU
- Publication Type:Journal Article
- Keywords:
Acute pancreatitis;
Raw rhubarb;
Mirabilite;
Integrated traditional Chinese and western medicine
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2016;23(5):475-478
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the clinical curative effect of applying large dose of raw rhubarb and mirabilite for treatment of patients with acute pancreatitis (AP).Methods A prospective study was conducted; 63 hospitalized patients with AP accompanied by bowel repletion heat bind syndrome identified by Traditional Chinese Medicine (TCM) differentiation method admitted to Sichuan Province Forestry Center Hospital from January 2012 to June 2015 were enrolled, and they were divided into an observation group (32 cases) and a control group (31 cases) according to random number table method. The two groups received western conventional treatment, additionally the control group applied Dachengqi decoction and Qingyi decoction with addition and subtraction of herbs according to the patient's individual situation (ingredients: radix bupleuri 15 g, radix paeoniae alba 15 g, the raw rhubarb (after) 15 g, radix scutellariae 9 g, rhizoma coptidis 9 g, radix aucklandiae 10 g, corydalis 15 g, mirabilite 9 g (a blunt), aurantii fructus immaurus 15 g, magnolia officinalis 15 g), while in the observation group, on the basis of treatment in the control group, additionally, a large dose of raw rhubarb 30 g decocted at last in the decoction and mirabilite 30 g in a large amount of drinking water were taken, 360 mL decoction was prepared for each one of the two groups, 120 mL per 8 hours was injected via a gastric tube, and after the injection of drug, the tube was closed for 1 hour. No adverse reactions were seen, and after the recovery of intestinal function, the method of taking decoction was changed to oral administration. When the daily defecation was above 3 times, the dose should be reduced, and more than five times, the drug should be withdrawn. The abdominal pain, abdominal distension relief time, blood amylase recovery to normal time, peritoneal irritation disappearance time, ventilation and defecation time, length of stay in hospital, cost of hospitalization, incidence of adverse reaction (abdominal pain), complications disappearance time and prognosis were observed in two groups.Results The abdominal pain and abdominal distension relief time (hours: 30.2±12.1 vs. 41.1±15.1), blood amylase recovery to normal time (hours:121±38 vs. 180±56), peritoneal irritation disappearance time (hours: 31.1±25.2 vs. 43.6±21.2), intestinal ventilation and defecation time (hours: 31.5±25.5 vs. 43.3±26.2), length of stay in hospital (days: 20.5±3.2 vs. 25.6±3.9), complications disappearance time (days:7.6±2.9 vs. 11.5±3.1) were significantly shortened in observation group than those in control group (allP < 0.05); the cost of hospitalization was lower in observation group than that in control group (yuan: 6 077 vs.7 589,P < 0.05). the incidence of adverse reactions (diarrhea) was higher in the observation group than that in the control group [18.75% (6/32) vs. 16.13% (5/31)], but there was no statistical significant difference between the two groups (P > 0.05).Conclusion The therapeutic effect of integrated conventional western medicine and dachengqi decoction and qingyi decoction with addition of a large dose of rhubarb and mirabilite for treatment of patients with acute pancreatitis is significantly better than that of using conventional dose of the above treatment without the addition.
