Bioinformatic analysis of the sequences of lamins from different species

VernacularTitle:斑马鱼核纤层蛋白Lamins的生物信息学分析
Author: Henglu ZHANG ; Huimin HUANG ; Zhixu YE ; Zhihua WANG ; Zhixu HE ; Liping SHU
Publication Type:Journal Article
Keywords: Zebrafish; Lamins; lmna gene; Phylogeny analysis; Synteny analysis
From: Acta Laboratorium Animalis Scientia Sinica 2016;24(4):351-357
CountryChina
Language:Chinese
Abstract: Objective Type A lamins are encoded by LMNA and a major component of the nuclear lamina, which have been suggested to play important roles in chromatin organization, transcription, DNA replication, and cell apoptosis. The aim of this study was to analyze the bioinformation of zebrafish lamins. Methods A phylogeny analysis was figured out with protein sequences of different species by Clustal X and MEGA 4?0 software. Then we compared the lamin protein sequences of different species with that of zebrafish by BLAST tool from NCBI. A figure of synteny analysis results was done with lamin sequence information of humans, murine and zebrafish cited from UCSC, Vega and Ensemble. Results The a?nalysis results showed that lmna, lmnb1, and lmnb2 genes of zebrafish are highly conservative and they may be homology of human LMNA, LMNB1 and LMNB2 genes. Conclusions Zebrafish lamins and human lamins have homologous sequence similarity, indicating that these two genes are orthologous genes.