Clinical Observation of TACE Combined with HIFU in the Treatment of Middle and Advanced Primary He-patocellular Carcinoma
10.6039/j.issn.1001-0408.2015.35.28
- VernacularTitle:肝动脉灌注化疗栓塞联合高强度聚焦超声治疗中晚期原发性肝癌的临床观察
- Author:
Siyu FU
;
Ruxian REN
;
Meijiang WANG
;
Yilin CHEN
;
Baohua JIANG
;
Qin ZHANG
- Publication Type:Journal Article
- Keywords:
Hepatic arterial chemoembolization;
High intensity focused ultrasound;
Middle and advanced hepatocellular carci-noma;
Therapeutic efficacy;
Safety
- From:
China Pharmacy
2015;26(35):4978-4980
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To observe therapeutic efficacy and safety of transcatheter arterial chemoembolization (TACE) com-bined with high intensity focused ultrasound (HIFU) in the treatment of middle and advanced primary hepatocellular carcinoma (HCC). METHODS:76 patients with middle and advanced primary HCC were randomly divided into treatment group(36 cases) and control group(40 cases). Control group was given TACE alone,and treatment group was additionally given HIFU 2-3 weeks after TACE. Clinical efficacy,the content of alpha-fetoprotein(AFP)before and after operation,survival rate,survival period and ADR were compared between 2 groups. RESULTS:The efficiency rate and total effective rate of treatment group were 61.1% and 94.4%,which were significantly higher than those of control group(35.0%,77.5%),with statistical significance(P<0.05). The content of AFP in 2 groups decreased significantly after operation,with statistical significance(P<0.05);there also was statistical significance between 2 groups(P<0.05). Survival rate of treatment group was higher than that of control group 24 and 36 months after operation,with statistical significance (P<0.05). The median survival time was 11.3 months in treatment group and 9.2 month in control group,with no statistical difference(P>0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Com-pared with TACE alone,TACE combined with HIFU in the treatment of middle and advanced primary HCC can improve long-term survival rate and the short-term efficacy,with good safety.
